Jan 16, 2013· Micronization, which reduces particles down to the micrometer or, in some cases, nanometer (1/1000 of a micrometer) size, can be used to improve the bioavailability of poorly soluble APIs by increasing particle surface area and accelerating dissolution rates. Micronization can …
Micronization is the process of reducing the average diameter of a solid material's particles. Traditional techniques for micronization focus on mechanical means, such as milling and grinding. Modern techniques make use of the properties of supercritical fluids and manipulate the principles of solubility.
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Titanium dioxide is produced by the sulfate process or chloride process. It is by far the most important white pigment today and is used in diverse fields which include, for example, applications in the life sciences, in biotechnology as well as in the pharmaceutical and cosmetics industries (e.g. lipstick, cream, ointment, toothpaste, sunscreen and powder).
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Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug compounds that limits in vivo bioavailability owing to their low dissolution rate in the gastrointestinal fluids following oral administration. The particle technology involves several approaches from the conventional size reduction processes to the newer, novel particle technologies that modify the ...
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Feed rate is the principle method of controlling particle size. Slower feed rates produce finer products and fast feed rates produce larger particles. Second to feed rate changes in grinding air pressure will change particle size. Additional methods are used to precisely control final particle size.